�Researchers at the Odense University Hospital, Denmark, give found that combining thalidomide with temozolomide may double its effectiveness, over temozolomide alone, for malignant malignant melanoma with brain metastases.
The non-randomised form II trial, published in the on-line journal ecancermedicalscience, investigated the combination of thalidomide and temozolomide. It is the first form II study combining a new cyclic regimen of temozolomide (150mg /m2 everyday, 7 years on 7days off) and thalidomide, for patients with malignant malignant melanoma suffering from brain metastases, to show a meaningful response charge per unit.
Melanoma is the third most coarse cause of metastases in the key nervous organization. Thalidomide is known to prevent young blood vessels growing from pre-existing vessels and thus inhibit tumour growth, and is also known to adjust the body's immune response. Temozolomide is a chemotherapy alkylating agent ordinarily used for primary brain tumours, simply also active in malignant melanoma.
The researchers observed a response rate of 17.5% for temozolomide and thalidomide combined, around doubly the reaction rate of the criterion schedule of temozolomide only (6-9% naturalized in a previous study).
A statistically significant correlation coefficient was establish between efficacy and lymphocytopenia (lowered e. B. White blood cell count).
Lead author Dr Lene Vestermark concluded: "The combination of temozolomide exploitation the dose-intense schedule and thalidomide at 100-200 mg/day is a safe regime leading to clinical efficacy in patients with learning ability metastases from malignant malignant melanoma.
Most importantly it seems that patients who acquire lymphopenia during therapy have a higher chance of obtaining objective response. The potential immunological mechanism behind this volition be the subject of future investigations, focusing on the potential drop benefit of regulatory T Cell down-regulation. The correlation between lymphocytopenia and objective response needs further probe."
Further evaluations using larger patient numbers and including different therapy schedules testament be considered for the future.
Temozolomide also known as Temodal or Thalomid
http://www.ecancermedicalscience.com
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Monday, 8 September 2008
Friday, 29 August 2008
'Gossip Girl' Star Ed Westwick Says Chuck Will Have 'More Of An Adventure' In Season Two
Mark your calendars, "Gossip Girl" fanatics: The much buzzed-about CW teen drama is returning to the airwaves for its second season on September 1 at 8 p.m. ET.
Currently, the gang is in Manhattan shooting all over the place, and Ed Westwick, who plays resident computer-aided design Chuck Bass, told MTV News that he's well-chosen to be back at work. "It's been great," he aforesaid. "It's been intense, and we're selfsame excited to get back on the air and get back out there.
"When you're working on it, and you're on the inside of it, you don't find yourself acquiring caught up in the buzz," Westwick added. "But we're mindful of it, and it's fantastic, and it makes us feel our work is a success."
The doer could solely reveal a bit around what fans have in store when the show returns. Of course, it almost goes without saying that you should expect lots of sex, drugs and pretty new faces. "There's new characters that are going to be introduced, and there will be twists and turns and all the common love triangles," he titillated. "And I think the issues and things that we touched on in season one will be explored more.
"Personally, my case has more of an adventure and more of an exploration of his motivations and why he is the way he is," he continued vaguely.
But what near Chuck's kinship with Leighton Meester's Blair Waldorf? In the time of year finale, Chuck got cold feet or so their relationship (and the hots for an interior designer), leaving Blair to jet off to France with a random young business white House. Everyone is dying to know if those two crazy, mischievous kids will make it work.
"Basically, we left off in season one with Chuck fashioning the decision not to pursue Blair, and I think he spent the summer contemplating that," he said. "When we add up back in season deuce, we see how he is with his decision."
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Tuesday, 19 August 2008
Download Basil Poledouris mp3
 Artist: Basil Poledouris: mp3 download Genre(s): Soundtrack Discography:  Starship Troopers - Complete Score CD1 Year: 1997 Tracks: 30  Starship Troopers - Complete Score - CD2 Year: 1997 Tracks: 16  Conan the Destroyer Year: 1990 Tracks: 13  Starship Troopers (33 Tracks) Year: Tracks: 33  Honor and Glory Year: Tracks: 15  Flight of the Intruder Year: Tracks: 14  Flesh and Blood (los secores del acero) Year: Tracks: 11 Composer Basil Poledouris has scored a wide-eyed smorgasbord show of major Hollywood features and idiot box movies of the '70s,'80s and '90s. Before breaking into the cinema industry Poledouris earned a music and composition degrees from Long Beach State University and accompanied both the Los Angeles moving-picture show school and the AFI school. He ofttimes collaborates with celluloid maker John Milius, whom he met spell attendance USC. In 1989, Poledouris standard an Emmy for the sexual conquest of the telecasting mini-series Lonesome Dove. |
Saturday, 9 August 2008
Elijah's Mantle
Artist: Elijah's Mantle
Genre(s):
Other
Discography:
Betrayals And Ectasies
Year: 1996
Tracks: 8
Remedies In Heresies
Year: 1994
Tracks: 7
Angels of Perversity
Year: 1993
Tracks: 9
Sorrows Of Sophia
Year:
Tracks: 7
Psalms From Invocation
Year:
Tracks: 10
Jolie's Twins Conceived Artificially?
Tuesday, 1 July 2008
Tuesday, 24 June 2008
Hariharan
Artist: Hariharan
Genre(s):
Easy Listening
Discography:
Buddham Saranam Gachchhami
Year: 2002
Tracks: 1
Wednesday, 11 June 2008
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