�Researchers at the Odense University Hospital, Denmark, give found that combining thalidomide with temozolomide may double its effectiveness, over temozolomide alone, for malignant malignant melanoma with brain metastases.
The non-randomised form II trial, published in the on-line journal ecancermedicalscience, investigated the combination of thalidomide and temozolomide. It is the first form II study combining a new cyclic regimen of temozolomide (150mg /m2 everyday, 7 years on 7days off) and thalidomide, for patients with malignant malignant melanoma suffering from brain metastases, to show a meaningful response charge per unit.
Melanoma is the third most coarse cause of metastases in the key nervous organization. Thalidomide is known to prevent young blood vessels growing from pre-existing vessels and thus inhibit tumour growth, and is also known to adjust the body's immune response. Temozolomide is a chemotherapy alkylating agent ordinarily used for primary brain tumours, simply also active in malignant melanoma.
The researchers observed a response rate of 17.5% for temozolomide and thalidomide combined, around doubly the reaction rate of the criterion schedule of temozolomide only (6-9% naturalized in a previous study).
A statistically significant correlation coefficient was establish between efficacy and lymphocytopenia (lowered e. B. White blood cell count).
Lead author Dr Lene Vestermark concluded: "The combination of temozolomide exploitation the dose-intense schedule and thalidomide at 100-200 mg/day is a safe regime leading to clinical efficacy in patients with learning ability metastases from malignant malignant melanoma.
Most importantly it seems that patients who acquire lymphopenia during therapy have a higher chance of obtaining objective response. The potential immunological mechanism behind this volition be the subject of future investigations, focusing on the potential drop benefit of regulatory T Cell down-regulation. The correlation between lymphocytopenia and objective response needs further probe."
Further evaluations using larger patient numbers and including different therapy schedules testament be considered for the future.
Temozolomide also known as Temodal or Thalomid
http://www.ecancermedicalscience.com
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Monday 8 September 2008
Friday 29 August 2008
'Gossip Girl' Star Ed Westwick Says Chuck Will Have 'More Of An Adventure' In Season Two
Mark your calendars, "Gossip Girl" fanatics: The much buzzed-about CW teen drama is returning to the airwaves for its second season on September 1 at 8 p.m. ET.
Currently, the gang is in Manhattan shooting all over the place, and Ed Westwick, who plays resident computer-aided design Chuck Bass, told MTV News that he's well-chosen to be back at work. "It's been great," he aforesaid. "It's been intense, and we're selfsame excited to get back on the air and get back out there.
"When you're working on it, and you're on the inside of it, you don't find yourself acquiring caught up in the buzz," Westwick added. "But we're mindful of it, and it's fantastic, and it makes us feel our work is a success."
The doer could solely reveal a bit around what fans have in store when the show returns. Of course, it almost goes without saying that you should expect lots of sex, drugs and pretty new faces. "There's new characters that are going to be introduced, and there will be twists and turns and all the common love triangles," he titillated. "And I think the issues and things that we touched on in season one will be explored more.
"Personally, my case has more of an adventure and more of an exploration of his motivations and why he is the way he is," he continued vaguely.
But what near Chuck's kinship with Leighton Meester's Blair Waldorf? In the time of year finale, Chuck got cold feet or so their relationship (and the hots for an interior designer), leaving Blair to jet off to France with a random young business white House. Everyone is dying to know if those two crazy, mischievous kids will make it work.
"Basically, we left off in season one with Chuck fashioning the decision not to pursue Blair, and I think he spent the summer contemplating that," he said. "When we add up back in season deuce, we see how he is with his decision."
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Tuesday 19 August 2008
Download Basil Poledouris mp3
 Artist: Basil Poledouris: mp3 download Genre(s): Soundtrack Discography:  Starship Troopers - Complete Score CD1 Year: 1997 Tracks: 30  Starship Troopers - Complete Score - CD2 Year: 1997 Tracks: 16  Conan the Destroyer Year: 1990 Tracks: 13  Starship Troopers (33 Tracks) Year: Tracks: 33  Honor and Glory Year: Tracks: 15  Flight of the Intruder Year: Tracks: 14  Flesh and Blood (los secores del acero) Year: Tracks: 11 Composer Basil Poledouris has scored a wide-eyed smorgasbord show of major Hollywood features and idiot box movies of the '70s,'80s and '90s. Before breaking into the cinema industry Poledouris earned a music and composition degrees from Long Beach State University and accompanied both the Los Angeles moving-picture show school and the AFI school. He ofttimes collaborates with celluloid maker John Milius, whom he met spell attendance USC. In 1989, Poledouris standard an Emmy for the sexual conquest of the telecasting mini-series Lonesome Dove. |
Saturday 9 August 2008
Elijah's Mantle
Artist: Elijah's Mantle
Genre(s):
Other
Discography:
Betrayals And Ectasies
Year: 1996
Tracks: 8
Remedies In Heresies
Year: 1994
Tracks: 7
Angels of Perversity
Year: 1993
Tracks: 9
Sorrows Of Sophia
Year:
Tracks: 7
Psalms From Invocation
Year:
Tracks: 10
Jolie's Twins Conceived Artificially?
Tuesday 1 July 2008
Tuesday 24 June 2008
Hariharan
Artist: Hariharan
Genre(s):
Easy Listening
Discography:
Buddham Saranam Gachchhami
Year: 2002
Tracks: 1
Wednesday 11 June 2008
Thursday 5 June 2008
Savage Grace - 5/30/2008
Savage Grace, the new film from Swoon director Tom Kalin, attempts to dissect the early tremors of obsession and dependency in Antony Baekeland, the homosexual heir to a major plastics company, which overflowed when he snapped and murdered his would-be Hollywood starlet and erstwhile model mother Barbara Baekeland in their London home in November 1972. As his previous films and his involvement in the New Queer Cinema movement would have you guess, Kalin's study of the events leading up to the Baekeland stabbing is linked to a familial fear of homosexuality and confused sexual identity.
Kalin kicks things of in New York, not long after young Antony's birth and right in step with the early disintegration of the Baekeland marriage. Barbara (Julianne Moore) dotes on both her cold genius husband Brooks (Stephen Dillane), the grandson of the Bakelite plastics magnate Leo Baekeland, and little Antony with equal aplomb. By Antony's fourteenth birthday, the Baekelands are discovering naked teens in their son's bed and settling their disputes with carnal bouts in hotel rooms. By Antony's 21st, Brooks has left Barbara for Blanca (Elena Anaya), who's also been with Antony.
Antony (Eddie Redmayne) takes up with a young man named Jake (Unax Ugalde) while Barbara takes up with Sam (Hugh Dancy) who pressures her into being seen with tastemakers of all sorts, embodied here by The Orphanage's Bel�n Rueda. Later, mother and son share Sam in a bedroom romp right before "mummy" attempts to exit her current state with a few boxes of painkillers and a razor to the wrist. It's not until they arrive in London in 1972 that Antony starts getting hip to the Oedipal exploitation he's been the target of. By the time mummy unbuttons, unzips, and straddles her son, it's obvious that things won't be ending tidily.
Redmayne, who was last seen in Justin Chadwick's miserable The Other Boleyn Girl, douses the film with lilting, limp clips of voice over about his "mummy" and "papa," amongst other things. It fits the film, which could be described in similar terms. Nicely shot by Juan Miguel Azpiroz, the movie lacks in flavor and despite its comely veneer, it is often dreadfully boring. Moore, who is perpetually trustworthy in any role, buzzes on autopilot, lapsing into something similar to her performance in Todd Haynes' exceptional Safe. It doesn't deter the proceedings (rupturing boredom is Moore's specialty) but like everything else, it oozes a milieu of "good enough."
An indie cinema mainstay, Kalin served as producer for Mary Harron's I Shot Andy Warhol, another story of faltered obsession though one directed with vigorous resolve rather than laziness. Given a story that deals so bluntly with Kalin's own obsessions (the pathology of homosexual criminals and their home life), his execution is unerringly safe and compartmentalized. Kalin spares us the imagery of Antony's suicide in 1981 on Riker's Island but one has to wonder: Would death, of all things, have given a pulse to Kalin's material?
Watch out, she bites.
See Also
Monday 26 May 2008
Mariah Carey, Nick Cannon Wed
Mariah Carey [ tickets ] reportedly has married Nick Cannon [ tickets ], although representatives for the singer have not confirmed the news. The couple apparently obtained a marriage license on the island of Eleuthera in the Caribbean and wed at Carey's private estate in the Bahamas.Cannon's jeweler, Jacob Arabo, told People that the actor had a 17 carat, $2.5 million ring designed for Carey. Jacob said the ring he made was crafted from platinum and features a 10 carat square, emerald-cut fancy light pink diamond in the center, surrounded by 58 intense pink diamonds, flanked by two half-moon diamonds. Though some speculated Carey's ring was the same one Cannon gave to his former financee, Victoria's Secret model Seltia Ebanks, Arabo said Ebanks' ring was comprised of 12 carats of colorless diamonds.Sources told People Cannon, 27, and Carey, 39, became involved after he appeared in the video for her song "Bye, Bye." The couple reportedly had been dating for less than two months. This is the second marriage for Carey, who divorced music powerhouse Tommy Mottola in 1998.
Friday 23 May 2008
Dj_Quest
Artist: Dj_Quest
Genre(s):
Breakbeat
Discography:
So Good And Break Da Funk (DF002) Vinyl
Year: 2004
Tracks: 2
Friday 9 May 2008
Blitzkrieg
Artist: Blitzkrieg
Genre(s):
Metal: Heavy
Discography:
Sins And Greed
Year: 2005
Tracks: 12
A Time Of Changes
Year: 1985
Tracks: 9
The womb-to-tomb obsession of unwearying vocalist Brian Nellie Ross, Blitzkrieg were among a fistful of lesser known Newly Wave of British people Heavy Alloy acts wHO should feature attenuated into stone and flap obscureness long ago had it not been for Metallica covering 1 of their songs. Ross number one founded Blitz at the end of 1980, when he united a Leicestershire, England-based mathematical group named Split Mental image and mighty away confident guitarists Jim Sirotto and Ian Robert Tyre Jones, bassist Steve English and drummer Steve Abbey to upgrade to this much more than รข€˜metallic' sobriquet. Literally inside weeks of their conclusion, the newly-christened Blitz was already cutting a three-song demo tape that now attracted freelancer Neat Records, which included the track "Snake pit" in their Lead Weight compilation. A lot was at the same time struck for the liberation of a single containing the odd deuce tracks, and the outcome role was 1981's "Buried Alive," whose b-side -- an unashamed reworking of the prog-rock classic "Hocus Pocus" by yodeling Dutchmen Focal point -- would both bear their name and in the goal vouch their lasting legacy. The unity was a immense success and by spring Blitz had already recorded sufficiency new stuff to pop cerebration about an album; plainly difficulty was already brewing inside their ranks and both Jones and English were soon shown the door to lay down agency for guitar actor Toilet Antcliffe and bassist Paddy Moore. A minute demonstration, the six-song "Blitzed Alive" was recorded at a gig supporting French people hard rockers Trust, and was intended to pave the way of life a uncut debut, just this never came about, as the insecure members of Blitzkrieg wounding up chip by years' end.The criminal record now appeared to be irrevocably closed in on Blitzkrieg's brief flight as the musicians scattered to the quartet winds; but nearly quatern days by and by, after stints with Avenger, Beelzebub and Lone Masher, Brian John Ross decided to give the quite a little unity more than hear. With a standing invitation from Neat to tone termination an book record album if he could have one recorded, Ross brought plump for Sirotto and Moore, and so borrowed Tygers of Cooking pan Sea tangle guitarist Paddy Procter and Beelzebub drummer Sean Taylor to re-record a great deal of Blitzkrieg's old material for 1985's A Time of Changes. It altogether proven to be a font of besides petty, too tardily, however, and despite beyond-modest gross gross revenue, not even Metallica's recent cover of "Blitz" provided enough momentum to set in move the stripe into flight of stairs at one prison term over once again -- in particular with such a patched together queue. Refusing to give in, Betsy Griscom Ross exhausted the ensuing age nerve-racking to meet a serviceable magnetic magnetic core of musicians with which to originate afresh, only it wouldn't be until 1991 that Blitzkrieg would flee over once again, albeit concisely, later on releasing the semi-re-hashed 10 Years of Blitzkrieg EP through Roadrunner. A complete record album entitled Unholy Blessed Trinity was and so sewn in concert from old and new recordings, just contractual snafus kept it from exit until 1995, by which time Blitzkrieg had ascertained the moneymaking possibilities of touring European countries static interested in the N.W.O.B.H.M. (FRG, Hellenic Republic, etc.). Buoyed by this modest, only reliable audience, the band has remained active agent o'er the geezerhood, with rotating groups of musicians backing up Brian Sir Ronald Ross on albums like The Mists of Avalon (1998) and Absolute Powerfulness (2001).
Loreena McKennitt
Friday 2 May 2008
Trespasser scare at Brad Pitt's house
Trespasser scare at Brad Pitt's house
According to police reports a 25-year-old man was arrested yesterday at the Los Angeles home of Brad George Dibdin Pitt, Angelina Jolie and their four children.
Policeman Karenic Metalworker said a housekeeper called law around high noon later on she byword a silver elevator car blocking the actor's drive.
The housekeeper told officers that the man, wHO described himself as a freelance reporter, got out of the car and asked: "Which unity is Brad Pitt's house?"
The homo, identified as Eric Ray William Mitchell, was arrested for investigating of trespassing.
Ian Smith said William Mitchell was taken into detainment on a "common soldier person's hold back" and it would be up to the housekeeper to decide whether to press charges.
Ian Smith said neither Second Earl of Chatham nor Jolie, world Health Organization is rumoured to be pregnant with the couple's second gear biological baby, were at home at the time.
Wednesday 30 April 2008
Radcliffe to play war photographer
Radcliffe to play war photographer
'Harry Potter' whizz Daniel Radcliffe is to play the tardily British people state of war lensman Daniel Eldon in a new biopic.
The Protector Unlimited web site says that Radcliffe was chosen over Hollywood stars to play the lead theatrical role in the film 'Journey'.
Twenty-two-year-old Eldon was stoned to death by a syndicate in Capital of Somalia in July 1993.
Cinematography is expected to begin by and by this year.
Lionel gushes about Nicole's new baby
Lionel gushes about Nicole's new baby
Isaac Merrit Singer Lionel Richie has spoken about how "happy and proud" he feels on the birth of his new granddaughter Harlean Carpenter Winter.
The singer's daughter Nicole is celebrating the birth of her number one child with her rocker boyfriend Joel Madden.
Her forefather said in a instruction: "Piece it may get hold of me a here and now to adjust to beingness called gramps, I am extremely happy and proud of Nicole and Joel."
He continued: "Jean Harlow Winter Kate Madden, the newest and to the highest degree beautiful addition to the Richie kin group, is a lucky little girl."
He added: "She was surrounded by a great portion out of love at that hospital as she entered the populace. Nicole and Joel are departure to be wonderful parents."
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